Atletico de San Luis vs. CF America Prediction, Match Preview and Betting Tips, 25 September 2025

This upcoming Liga MX clash between Atletico de San Luis and CF America on 25 September 2025 is shaping up to be an intriguing affair. Hosted at Estadio Alfonso Lastras, the match sees 11th-placed San Luis welcoming the formidable 4th-placed America.
San Luis, under the guidance of Guillermo Abascal, have been inconsistent recently, recording a WLLDW form. Their top scorer, Joao Pedro, who has netted 8 times this season, will be vital in their efforts. However, they face a tough challenge against Paulo Victor’s CF America, who are in strong form (WWWLD) and are the bookmaker favourites with odds of 1.62 for an away win.
America has shown strong offensive prowess, scoring in all their away matches this season. With players like Brian Rodriguez and Allan Saint-Maximin, they are a team to be reckoned with. The recommended bet: an away win for CF America, seems a sensible choice given their current form and past results.

Atletico de San Luis vs CF America Prediction & Betting Tip

Our recommended betting tip for this match is an Away Win for CF America (1.62).

Here are three reasons why this prediction is a solid choice:

1. Form and Standing: CF America is in superior form (WWWLD) and stands 4th in the league, while Atletico de San Luis (WLLDW) is in 11th place.
2. Scoring and Defense: CF America scores an average of 2.00 goals per match and has scored in all their away games this season. In contrast, Atletico concedes 1.67 goals per match, showing defensive vulnerabilities.
3. Head-to-Head Advantage: CF America has won 3 of the last 5 encounters against Atletico de San Luis, showcasing a historical edge.

Given these factors, an away win for CF America is the most supported outcome.

Atletico de San Luis vs CF America Odds

The betting odds for this Liga MX matchup between Atletico de San Luis and CF America on 25 September 2025 favour the away team. Given CF America’s strong form and superior league standing, it’s no surprise they are the bookmaker favourites.

CF America is in strong form, having secured three wins in their last five games. They also have a historical advantage over Atletico de San Luis, making them a solid pick for this encounter.
Atletico de San Luis, while not pushovers, have shown defensive vulnerabilities, conceding an average of 1.67 goals per match. This further supports the prediction that CF America is likely to come out on top.

Atletico de San Luis Team Analysis

Recent Performance:

Atletico de San Luis has been struggling with consistency in their recent outings. With a form of WLLDW, they are currently positioned 11th in the league standings, having accumulated 10 points.
Their performances over the last five matches have been a mixed bag:

• Santos Laguna 1 – 4 Atletico de San Luis (W)
• Atletico de San Luis 1 – 1 Tijuana (D)
• Atletico de San Luis 1 – 3 Toluca (L)
• Queretaro FC 3 – 2 Atletico de San Luis (L)
• Puebla 0 – 2 Atletico de San Luis (W)

In these games, they have managed to score an average of 2.00 goals per match, which indicates solid offensive capabilities. However, they’ve only kept one clean sheet in the last five games, showcasing some defensive vulnerabilities.
Given these results, Atletico will need to tighten up at the back and capitalize on their attacking prowess, particularly through their top scorer, Joao Pedro, who has netted 8 goals this season.

Atletico de San Luis Key Players

Atletico de San Luis will be heavily reliant on their top scorer, Joao Pedro, who has already netted 8 goals this season. His goal-scoring prowess will be crucial as they look to break down CF America’s defence.
Another key figure will be Andres Sanchez, their goalkeeper, who will need to be in top form to keep out America’s formidable attack, led by players like Brian Rodriguez and Allan Saint-Maximin.
The midfield battle will be pivotal, with Oscar Macias and Sebastien Lamonge expected to thwart America’s creative midfielders.
Expected lineup for Atletico de San Luis:

• Goalkeeper: Andres Sanchez
• Defenders: Roman Torres, Eduardo Aguila, Robson Bambu, Juan Manuel Sanabria
• Midfielders: Oscar Macias, Sebastien Salles Lamonge, Miguel García, Sebastián Pérez Bouquet, Benjamin Galdames
• Forward: João Pedro Galvão

Atletico de San Luis Suspensions & Injuries

Atletico de San Luis are dealing with a couple of notable injuries that could impact their performance. Cesar Ivan Lopez is out with a cruciate ligament injury, with a potential return not expected until mid-April 2026. Additionally, Juanpe is doubtful due to a knock injury.
The absence of these players could be significant. Cesar Ivan Lopez’s long-term absence means San Luis might have to adjust their defense strategy, while Juanpe’s potential unavailability could disrupt the midfield dynamics.
Without these players, Atletico de San Luis will rely heavily on the fitness and form of the remaining squad members, especially those filling in these critical positions.

Atletico de San Luis Tactics and Formation

Atletico de San Luis will likely stick to their familiar 4-2-3-1 formation as they prepare to face CF America.
Tactical Breakdown:

• Formation: 4-2-3-1
• Key Forward: Joao Pedro
• Midfield Duo: Oscar Macias and Sebastien Lamonge
• Defensive Layout: Roman Torres, Eduardo Aguila, Robson Bambu, Juan Manuel Sanabria
• Notable Strategy: Atletico de San Luis tend to score most of their goals between the 61-75 minute interval, indicating a strong push in the latter stages of the game.

Expected Lineup for Atletico de San Luis:

• Goalkeeper: Andres Sanchez
• Defenders: Roman Torres, Eduardo Aguila, Robson Bambu, Juan Manuel Sanabria
• Midfielders: Oscar Macias, Sebastien Lamonge, Miguel García, Sebastián Pérez Bouquet, Benjamin Galdames
• Forward: João Pedro Galvão

This blend of a solid defensive setup and a potent attacking force, led by the prolific Joao Pedro, will form the backbone of their tactics.

CF America Team Analysis

Recent Performance:

CF America has been in impressive form lately, consolidating their position in the top echelons of Liga MX. With a recent form of WWWLD, they sit comfortably in 4th place, amassing 18 points.
Their last five matches have shown a blend of attacking force and defensive resilience:

• Monterrey 2 – 2 CF America (D)
• CF America 1 – 2 CD Guadalajara (L)
• CF America 2 – 0 Pachuca (W)
• Atlas 2 – 4 CF America (W)
• Tigres 1 – 3 CF America (W)

In these fixtures, they have averaged a strong 2.40 goals per match, showcasing their offensive capabilities. They have also managed to secure one clean sheet in their last five games. CF America’s consistency in front of goal and ability to grind out results make them a formidable opponent.
Given their current form, CF America will be looking to capitalize on Atletico de San Luis’s defensive vulnerabilities.

CF America Key Players

CF America’s key players will play a pivotal role in this match. Brian Rodriguez, leading with 3 goals this season, will be essential in breaking down Atletico de San Luis’s defense. Allan Saint-Maximin, another offensive threat, will look to exploit the flanks with his pace and skill.
In midfield, players like Alan Cervantes and Alexis Gutierrez will look to dominate possession and create opportunities for the forwards. Israel Reyes Romero’s role as a defensive midfielder will be crucial in breaking up San Luis’s attacks.
Expected lineup for CF America:

• Goalkeeper: Luis Malagon
• Defenders: Dagoberto Espinoza, Sebastián Cáceres, Ramon Juarez, Cristian Borja
• Midfielders: Israel Reyes Romero, Alan Cervantes, Alejandro Zendejas, Alexis Gutierrez, Allan Saint-Maximin
• Forward: Jose Zuniga

Individual battles, such as Allan Saint-Maximin against Roman Torres, could be decisive in determining the outcome.

CF America Suspensions & Injuries

CF America is currently dealing with a few injury concerns that could affect their lineup. Santiago Naveda is doubtful due to a muscle injury, Jonathan dos Santos is sidelined with a calf injury and is expected back in a few weeks, while Henry Martin is recovering from a knee injury and is slated for a potential return around late September 2025.
The absence of these players, particularly Jonathan dos Santos in midfield and Henry Martin in attack, might impact America’s depth and strategy. Nonetheless, the team has shown resilience and has other key players like Brian Rodriguez stepping up, which should help to mitigate these absences as they take on Atletico de San Luis.

CF America Tactics and Formation

CF America is expected to deploy their favored 4-2-3-1 formation as they face Atletico de San Luis.
Tactical Breakdown:

• Formation: 4-2-3-1
• Key Forward: Jose Zuniga
• Midfield Core: Alan Cervantes and Israel Reyes Romero
• Defensive Backbone: Dagoberto Espinoza, Sebastián Cáceres, Ramon Juarez, Cristian Borja
• Notable Strategy: CF America excels in maintaining high offensive pressure throughout the match, as evidenced by their scoring in every away game this season.

Expected Lineup for CF America:

• Goalkeeper: Luis Malagon
• Defenders: Dagoberto Espinoza, Sebastián Cáceres, Ramon Juarez, Cristian Borja
• Midfielders: Israel Reyes Romero, Alan Cervantes, Alejandro Zendejas, Alexis Gutierrez, Allan Saint-Maximin
• Forward: Jose Zuniga

This formation allows CF America to balance defensive solidity with attacking flair, primarily through their wingers and forward players who will look to exploit any weaknesses in the San Luis defence.

Atletico de San Luis vs CF America Head-to-Head Statistics

Looking at the recent head-to-head encounters, CF America has had the upper hand over Atletico de San Luis in their last five meetings:

• CF America 3 – 0 Atletico de San Luis (2025-01-29, Liga MX Clausura)
• Atletico de San Luis 2 – 1 CF America (2024-07-06, Liga MX Apertura)
• CF America 2 – 1 Atletico de San Luis (2024-03-30, Liga MX Clausura)
• CF America 0 – 2 Atletico de San Luis (2023-12-10, Liga MX Apertura Playoff)
• Atletico de San Luis 0 – 5 CF America (2023-12-07, Liga MX Apertura Playoff)

These results show that CF America has emerged victorious in three of the last five games. Their latest encounter saw CF America securing a decisive 3-0 win, indicating their recent dominance over San Luis.
Atletico de San Luis did manage a notable 2-1 win in July 2024, showing they can be competitive. However, given the current form and previous match outcomes, CF America holds a psychological and performance edge heading into this fixture.

Odds accurate as of 23/09/2025 04:04, and are subject to change. Please always check the odds before placing your bets with any bookmaker.